Abstract:·AIM: To study the relationship between ocular parameters and lens thickness in myopia subjects with different anterior chamber depths. ·METHODS: A cross-sectional study. A total of 118 myopic subjects (236 eyes) underwent posterior chamber phakic implantable collamer lens (Phakic-ICL) in the refractive department of Putian Eye Hospital from 2022-05 to 2024-05. Ocular parameters examined before surgery included uncorrected visual acuity (UCVA), subjective refraction, best corrected visual acuity (BCVA), contactless intraocular pressure (IOP), anterior chamber depth (ACD), white-to-white corneal diameter (WTW), horizontal sulcus-to-sulcus diameter (STSH), vertical sulcus-to-sulcus diameter (STSV), and lens thickness (LT). Pentacam measured ACD without corneal thickness. Meanwhile, subjects were divided into three groups: shallow anterior chamber group (2.8mm≤ACD≤3.2mm), middle anterior chamber group (3.2mm < ACD≤3.4mm), and deep anterior chamber group (ACD > 3.4mm). One-way analysis of variance (ANOVA) and the Bonferroni method was used to study the differences between WTW, STSH, STSV, and LT among groups, and Pearson correlation was used to analyze the correlation between the above parameters under different anterior chamber depth groups and overall situation, as well as the Multiple linear regression analysis was operated to research LT with the above ocular parameters under different ACD groups. ·RESULTS: The Bonferroni test was used to compare the two groups, showed no statistically significant difference in LT between the middle ACD group and the deep ACD group (P=1), and there were statistically significant differences in LT between shallow to middle ACD groups (P < 0.01) and shallow to deep ACD groups (P < 0.05); however, there were statistically significant differences in WTW, STSH and STSV among different ACD groups (F=226.36, F=15.58, F=11.92; All P < 0.01). LT was negatively low correlated with ACD only in the shallow ACD group and total data group (r = -0.222, P < 0.01; r = -0.231, P < 0.05). There was no correlation in LT and ocular parameters between the middle ACD group and deep ACD group (P > 0.05); moderate correlations were discovered among WTW, STSH and STSV in different ACD groups and overall data (P < 0.01); in the total data group, ACD had low correlations with WTW, STSH, STSV and LT (all P < 0.01). Through multiple linear analyses, it was found that only the shallow ACD group and the total data group had statistically significant independent variables that were linearly correlated with LT, and their equations were as follows: LTS=5.492-0.167×WTW+0.267×STSV-0.448×ACD; LTT=3.884-0.303×ACD, the corrected R2 of equations showed low values, revealed 0.141 and 0.056, respectively. ·CONCLUSION: Among different ACD groups, there was no correlation or linear relationship between LT and WTW, STSH and STSV; in the shallow ACD group and the total data, LT had a low negative correlation with ACD, and its multiple linear regression fit was low, only (0.141,0.056). Therefore, there is no Linear relationship between lens thickness and ocular diameter parameters under different anterior chamber depth groups.
