Abstract:AIM: Optical coherence tomography angiography was used to explore the effect of erlotinib on the thickness of corneal epithelium and cornea in mice.
METHODS: Totally 20 mice were randomly divided into experimental group and PBS group. Erlotinib eye drops was prepared. Erlotinib eye drops and PBS were applied to the two groups of mice at 8, 12, 16 and 20 o'clock each day. OCTA was used to measure the 17 regions of the epithelium and corneal thickness at 1wk, 2wk and 3wk before and after the eye droppings.
RESULTS: There was no significant difference in the thickness of corneal epithelium and cornea between the experimental group and PBS group(all P>0.05). Two weeks after eye dropping, the areas of M, T5, IT5, I5, IN5, N5, T6, IT6, IN6 and N6 in the epithelium and corneal of experimental group were significantly thicker than those of PBS group(all P<0.05). In the third week, 17 areas of epithelium and cornea in experimental group were significantly thicker than those of PBS group(all P<0.05). After treatment with 2 and 3wk in erotinib group and PBS group, there were differences in the average corneal epithelial thickness and the total corneal thickness between each group(all P<0.05). According to the trend analysis of the average change of corneal epithelium and corneal thickness, there were differences between the erotinib group and the PBS group(all P<0.05).
CONCLUSION: Using OCTA, it can be found that ellotini has the effect of thickening corneal epithelium and cornea, and the effect is more obvious with the increase of application times.
