Choroidal thickness and the relevant factors of high myopia amblyopic among Chinese children

Abstract:

AIM: To compare posterior choroidal thickness in high myopia amblyopia eyes at different points to high myopia and normal eyes of Chinese children and investigate the relationships between choroidal thickness, axial length and age.

METHODS: Fifty Chinese children(65 eyes)with age 4～15 years(mean 9.91±3.41 years)were recruited. By atropine optometry they were divided into high myopia amblyopia group(24 eyes), high myopia group(19 eyes), and normal group(22 eyes). Choroidal scans were obtained for all eyes using enhanced depth imaging spectral-domain optical coherence tomography(EDI-OCT). Subfoveal choroidal thickness(SFCT), macular thinkness, choroidal thickness and retinal thickness at 0.5, 1.0, 1.5, 2.0, 2.5, 3.0mm superior(S, 12:00 position), temporal(T, 9:00 position), inferior(I, 6:00 position), nasal(N, 3:00 position)were measured. Meanwhile, axial lengths of all eyes were measured by A-Scan.

RESULTS: Compared high myopia group and emmetropia group, SFCT and the thickness of choroids on each position were thinnest in high myopic amblyopia group, with statistically significant differences(P<0.05). There was a significant negative correlation between SFCT and axial length in high myopic amblyopia group(r=-0.531, R²=0.282, F=7.476, P=0.013), with no relative in age(r=-0.292, R²=0.085, F=2.044, P=0.167).

CONCLUSION: The choroidal thickness thinning in high myopic amblyopia shows a negative correlation with axial length.

Key words:high myopia; amblyopia; choroidal thickness; axial length; optical coherence tomography; enhanced imaging