Study on factors related to central corneal thickness in patients with myopia

Abstract:

AIM: To determine the factors related to central corneal thickness (CCT) in patients with myopia. METHODS: A total of 307 patients (614 eyes) of myopia or myopia astigmatism subjects were examined. Refraction was measured by CANON RK-F1 automatic-refractor. CCT was measured by Pachymeter SP 3000. Axial Length was measured by A-mode ultrasound （OPTIKON 2000）.Intraocular pressure (IOP) was measured by CANON TX-F non-contact tonometer. Corneal curvature was measured by Orbscan II（BAUSCH& LOMB）. Age was also analyzed. The relationships between CCT and other parameters were tested by Pearson-s correlation and linear regression analysis. RESULTS: The average CCT was 542.30±33.52μm. CCT was positively correlated with IOP (r=0.303,P=0.000),negatively correlated with average corneal curvature (r= -0.129,P=0.001). There were no significant correlations between the CCT and age(r=-0.050,P=0.213), refractive error (r=0.024,P=0.561), axial length (r=0.061,P=0.131) and anterior chamber depth（r=-0.031,P=0.445）. CONCLUSION: The CCT was correlated with IOP and average corneal curvature in patients of myopia. If the average CCT increases 100μm, the IOP would increase 24mmHg.