Safety analysis of plasminogen activators in intraocular application
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Xiangjiang Public Welfare Foundation Special Project for Technology Innovation and Application Development(No.KY24003)

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    Abstract:

    Plasminogen activator is a kind of enzyme that plays a key role in the process of physiological hemostasis and thrombolysis. Its main function is to convert plasminogen into active plasmin, thereby initiating the dissolution of fibrin and maintaining blood mobility. This article discusses the safety of plasminogen activator in the intraocular application, elaborates on the types, structure, physiological function and mechanism of action of plasminogen activator in the eye. The analysis addresses the ocular tissue damage and systemic adverse reactions that may be caused by the application of plasminogen activator in the eye, and the risks and countermeasures combined with relevant research examples, aiming to provide reference for the safe application of plasminogen activator in clinical practice.

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Tang Miao, Zhang Jinsong, Yu Haisheng. Safety analysis of plasminogen activators in intraocular application. Guoji Yanke Zazhi( Int Eye Sci) 2026;26(4):646-650

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Publication History
  • Received:August 26,2025
  • Revised:February 28,2026
  • Adopted:
  • Online: March 17,2026
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