Abstract:Myopia has become a growing public health issue globally, characterized by an earlier age of onset and a rising annual incidence rate，particularly among adolescents. Repeated low-intensity red light therapy (RLRL) has gained widespread attention in recent years as an emerging non-invasive intervention, showing promise for controlling myopia. This article examines the role of the PI3K/AKT signaling axis in RLRL-induced effects，specifically its mediation of endothelial nitric oxide synthase (eNOS) phosphorylation to promote choroidal thickening. Choroidal thickening is recognized as a critical mechanism in controlling myopia. Activation of the PI3K/AKT/eNOS/NO signaling pathway may attenuate axial elongation by enhancing choroidal blood flow and nutrient supply. Although preliminary preclinical and clinical studies support this mechanism,numerous unanswered questions remain, such as the underlying mechanisms of RLRL action, its safety, and its applicability in different populations. This article systematically reviews the relevant research progress, aiming to provide a valuable reference for future studies and elucidate the potential applications of RLRL in myopia prevention and control.
