Mechanism of action and therapeutic potential of the Hippo signaling pathway in ocular disease

doi:10.3980/j.issn.1672-5123.2024.11.14

Home > Archive>Volume 24, Issue 11, 2024 >1764-1768. DOI:10.3980/j.issn.1672-5123.2024.11.14

Mechanism of action and therapeutic potential of the Hippo signaling pathway in ocular disease
DOI:
                        10.3980/j.issn.1672-5123.2024.11.14
                    
Author:
                        Deng LiyaDeng Liya
Aier School of Ophthalmology, Central South University, Changsha 410015, Hunan Province, China
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Wang YingWang Ying
Aier School of Ophthalmology, Central South University, Changsha 410015, Hunan Province, China; Liaoning Aier Eye Hospital, Shenyang 110000, Liaoning Province, China
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Fund Project:Natural Science Foundation of Hunan Province(No.2023JJ70043); Young and Middle-aged Science and Technology Innovation Talent Support Program of Shenyang(No.RC210392)

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Abstract:

Hippo signaling pathway plays an important role in cell growth, proliferation, apoptosis, and stem cell regeneration. Dysregulation of this pathway has been linked to various diseases, such as cancer, heart disease, lung disease, kidney disease, liver disease, and immune dysfunction, as well as ocular diseases. Consequently, regulating the balance of Hippo signaling pathway may be an effective treatment for ocular diseases. This article reviews the mechanism of action and therapeutic potential of Hippo signaling pathway in ocular diseases, and discusses the potential therapeutic targets of the Hippo signaling pathway, to identify new targets and provide new research ideas for treating ocular diseases.

Key words:Hippo signaling pathway; ocular diseases; treatment

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Deng Liya, Wang Ying. ,/et al.Mechanism of action and therapeutic potential of the Hippo signaling pathway in ocular disease. Guoji Yanke Zazhi( Int Eye Sci) 2024;24(11):1764-1768

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Publication History

Received:December 20,2023
Revised:September 12,2024
Adopted:
Online: October 18,2024
Published:

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