Clinical observation of Conbercept intravitreal injection combined with retinal laser photocoagulation therapy on macular edema secondary to retinal vein occlusion

Abstract:

AIM:To study the efficacy of conbercept intravitreal injection combined with retinal laser photocoagulation therapy and simple laser photocoagulation therapy on macular edema(ME)secondary to retinal vein occlusion(RVO).

METHODS: Forty-eight patients(53 eyes)with macular edema secondary to retinal vein occlusion diagnosed by clinical examination from October 2014 to March 2015 were retrospectively analyzed. Among them, 28 patients(31 eyes)were treated with conbercept intravitreal injection combined with retinal laser photocoagulation, which was defined as Group A. And simple laser group contained 20 patients(22 eyes), which was defined as Group B. The clinical data including the patients' best-corrected visual acuity(BCVA)and central retinal thickness(CMT)before treatment and 1wk and 3mo after treatment were observed.

RESULTS: Followed up for 3mo, the average BCVA values of A and B were 0.44±0.25,0.56±0.24, respectively and the average CMT were 330.50±121.71, 354.67±102.79μm at first week of treatment. There was no significant difference in BCVA and CMT of Group A compared with Group B. There was statistically significant in BCVA and CMT of Group A and Group B compared with before treatment(P<0.05). The average BCVA values of A and B were 0.24±0.18, 0.39±0.20, respectively and the average CMT were 252.62±83.01, 332.67±102.33μm at third month of treatment. There were statistically significant differences between the two groups and compared with before treatment(P<0.05), and Group A was superior to Group B.

CONCLUSION: Conbercept intravitreal injection combined with retinal laser photocoagulation therapy and simple laser photocoagulation treatment of macular edema secondary to retinal vein occlusion are both effective that macular edema is significantly reduced, and vision is stable and improved. But for serious cases, conbercept intravitreal injection can reduce retinal edema at first, then combine with retinal laser photocoagulation which has obvious therapeutic effect and it is better than simple laser photocoagulation treatment.

Key words:retinal vein occlusion; macular edema; conbercept ophthalmic injection; retinal photocoagulation