Association of the single nucleotide polymorphisms in the calcitonin receptor-like receptor gene with primary angle closure in a Han Chinese population

Abstract:

AIM: To study the association of the single nucleotide polymorphism(SNP)rs1157699 in the calcitonin receptor-like receptor(CRLR)gene with primary angle closure(PAC)in a Han Chinese population.

METHODS: All samples, involved 232 PAC cases and 306 controls, were obtained from an epidemiologic survey conducted in Funing, Jiangsu Province, China. Genotyping were carried out by TaqMan-MGB probe using the real time quantitative polymerase chain reaction system to study the relationship between SNP of rs1157699 in CRLR gene and PAC.

RESULTS: The prevalence of CRLRrs1157699 genotype was 67.4%, 30.0%, 2.6% for CC, CT, TT in cases, and 71.3%, 27.0%, 1.7% in controls respectively. There was no difference between the two groups in the distribution of genotype and allele frequencies of rs1157699(P>0.05).

CONCLUSION: Our results do not support a significant role for rs1157699 in CRLR with PAC.

Key words:primary angle closure; calcitonin receptor-like receptor gene; single nucleotide polymorphism; Han Chinese population