The formation of rats' choroidal neovascularization induced by acrolein

doi:10.3980/j.issn.1672-5123.2016.4.01

Home > Archive>Volume 16, Issue 4, 2016 >591-593. DOI:10.3980/j.issn.1672-5123.2016.4.01

The formation of rats' choroidal neovascularization induced by acrolein
DOI:
                        10.3980/j.issn.1672-5123.2016.4.01
                    
Author:
                        Guan-Feng WangGuan-Feng Wang
Department of Ophthalmology,The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
Xiu-Lan ZouXiu-Lan Zou
Department of Ophthalmology,The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
Dong-Hao LiDong-Hao Li
Department of Ophthalmology,The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
Chen WangChen Wang
Department of Ophthalmology,The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
Wen-Li LiWen-Li Li
Department of Ophthalmology,The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
Rong-Biao PiRong-Biao Pi
Department of Ophthalmology,The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site

                    
Corresponding Author:
Affiliation:
Clc Number:
Fund Project:The Third Affiliated Hospital of Guangzhou Medical University Research Product(No. 2013Y06); Guangdong Province Science and Technology Project(No. 2012B031800419)

Article

Figures

Metrics

Reference

Cited by

Materials

Comments

Abstract:

AIM:To investigate the formation of rats' choroidal neovascularization(CNV)induced by acrolein.

METHODS:Twelve Sprague-Dawley rats were randomly divided into three groups. Acrolein 200μL(2.5 mg/kg/d)was poured into the rats' stomach for 4wk as acrolein 4wk and for 8wk as acrolein 8wk group. The same volume of fresh water was also done to the rats as the control group. Remove all eye balls and embed into paraffin with HE staining.

RESLUTS:The RPE-Bruch membrane was intact with no obvious abnormality in the control group and acrolein 4wk group. Lost in the continuity of RPE and the movement of choroidal neovascularization were found in the acrolein 8wk.

CONCLUSION:The long time use of acrolein can induce the formation of choroial neovascularization in rats.

Key words:acrolein; choroidal neovascularization; rat

Get Citation

Guan-Feng Wang, Xiu-Lan Zou, Dong-Hao Li,/et al.The formation of rats' choroidal neovascularization induced by acrolein. Guoji Yanke Zazhi( Int Eye Sci) 2016;16(4):591-593

Copy

Article Metrics

Abstract:
PDF:
HTML:
Cited by:

Publication History

Received:September 08,2015
Revised:December 04,2015
Adopted:
Online: March 28,2016
Published:

Home

Instructions for Authors

Call for Papers

Journal overview

Article Search

Contact us

Email Alert

RSS

Get Citation

Share

Article Metrics

Publication History