Abstract:AIM:To study the effect of β-blockers combined with carbonic anhydrase inhibitors on postoperative intraocular pressure(IOP)control of neovascular glaucoma.
METHODS:Seventy-four patients(80 eyes)with neovascular glaucoma received surgical treatment in our hospital from May 2012 to October 2014 were randomly divided into observation group and control group. Observation group received β-blockers combined with carbonic anhydrase inhibitors treatment. Control group received monotherapy of β-blocker. Then IOP, cytokine levels, curative effect were compared between the two groups.
RESULTS:Curative effect:the efficacy rate of observation group(93%)was significantly higher than that of control group(74%, χ2=4.931, P<0.05); IOP level:at 3mo after treatments, average IOP, IOP peak, IOP fluctuation of observation group were significantly lower than those of the control group(t=13.422, 11.555, 8.129, P<0.05); Cytokines:at 7d after treatments, serum and aqueous humor vascular endothelial growth factor(VEGF)and interleukin-6(IL-6)of observation group content were significantly lower than those of the control group, pigment epithelium derived factor(PEDF)was significantly higher than that of the control group(t=11.762, 7.608, 5.275, 3.780, 7.450, 2.625, P<0.05).
CONCLUSION: The therapy of β-blockers combined with carbonic anhydrase inhibitors can help to reduce the level of postoperative IOP in neovascular glaucoma patients, regulate the synthesis of cytokines, and then improve therapy effect.
