Abstract:Traumatic optic nerve injury(TON)is caused by direct or indirect optic nerve trauma, which is one of a serious complication of craniocerebral trauma. Its prognosis poor and usually bring permanent vision damage. At present, optic nerve injury and regeneration is hot in neurobiology research. To build an ideal experimental animal model is extremely important in research and development in the treatment of optic nerve injury. In this article, we review the methods of making rat models of traumatic optic neuropathy, clinical similarities, advantages and disadvantages of among these models, to provide reference for more experimental study.
