Clinical observation of diabetic retinopathy after transplantation of autologous stem cell in diabetic patients
Author:
  • Article
  • | |
  • Metrics
  • |
  • Reference [18]
  • |
  • Related [20]
  • | | |
  • Comments
    Abstract:

    AIM: To observe the effect of autologous stem cell transplantation in diabetic retinopathy.

    METHODS:Totally 58 cases(116 eyes)who underwent autologous stem cell transplantation were confirmed as no diabetic retinopathy(18 eyes), mild non-proliferative diabetic retinopathy(NPDR)(41 eyes), mid-level NPDR(51 eyes); severe NPDR(6 eyes)by ophthalmoscope directly or indirectly and fluorescence fundus angiography(FFA). Follow-up was 6-12mo, the changes of retinopathy were observed.

    RESULTS:The total effective rate of vision and retinopathy was 84.4%, 76.7%. The results of severe NPDR was statistically worse than the other groups(P< 0.05).

    CONCLUSION:The stable blood glucose level and improved pancreatic function after autologous stem cell transplantation might be helpful in diabetic retinopathy, the long effects need to be researched further.

    Reference
    1 Falkenberg M,Finnstrom K.Associations with retionpathy in type 2 diabetes:a population-based study in a Swedish rural area. Diabet Med 1994; 11(8):843-849
    2 Xie XW,Xu L,Wang YX,et al. Prevalence an associated factors of diabetic retinapothy.The Beijing eye study 2006.Graefes Arch Clin Exp Ophthalmol 2008; 246(11):1519-1526
    3罗洁,赵菊莲,游志鹏.糖尿病视网膜病变危险因素的研究现状.中国实用眼科杂志2011; 29(1):14-17
    4胡利,李东豪,陈慧.糖尿病患者血糖控制相关因素与糖尿病视网膜病变发生的关系.中华眼底病杂志2011; 27(3):210-213
    5 Shiraiwa T,Kaneto H,Miyatsuka T,et al.Postprandial hyperglycemia is a better predictor of the progression of diabetic retinopathy than HbAlc in Japanese type 2 diabetic patients.Diabetes Care 2005; 28(5):2806-2807
    6 Balkau B,Eschwege E.Epidemiological data on postprandial Glycaemia.Diabetes Metab 2006; 32(2):2-9
    7 Brownlee M,Hirsch IB.Glycemic variability:a hemoglobin A1c-independent risk factor for diabetic complications. JAMA 2006; 295(9):1707-1708
    8 Ceriello A,Esposito K,Piconi L,et al.Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients.Diabetes 2008; 57(4):1349-1354
    9 Kohnert KD,Augstein P,Zander E,et al.Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents. Diabetes Care 2009; 32(6):1058-1062
    10 Lu M,Amano S,Miyamoto K,et al.Insulin-induced vascular endothelial growth factor expression in retina. Invest Ophthalmol Vis Sci 1999; 40(4):3281-3286
    11 Samnegard B,Jacobson SH,Jaremko G,et al.Effects of C-peptide on glomerular and renal size and renal function in diabetic rats.Kidney Int 2001; 60(3):1258-1265
    12 Johansson BL,Sjoberg S,Wahren J.The influence of human Gpeptide on renal function and glucose utilization in type 1(insulin-dependent)diabetic patients. Diabetologia 1992; 35(5):121-128
    13 Bhansali A,Upreti V,Khandelwal N.Efficacy of autologous bone marrow- derived stem cell transplantation in patients with type 2 diabetes mellitus. Stem Cells Dev 2009; 18(10):1407-1416
    14 Li L,Shen S,Ouyang J.Autologous hematopoietic stem cell transplantation modulates immunocompetent cells and improves beta-cell function in Chinese patients with new onset of type 1 diabetes. J Clin Endocrinol Metab 2012; 97(5):1729-1736
    15 Wang L,Zhao S,Mao H.Autologous bone marrow stem cell transplantation for the treatment of type 2 diabetes mellitus. Chin Med J(Engl) 2011; 124(22):3622-3628
    16 Li L,Gu W,Zhu DJ.Novel therapy for type 1 diabetes: autologous hematopoietic stem cell transplantation. Diabetes 2012; 4(4):332-337
    17 Fadini GP,Losordo D,Dimmeler S.Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use. Cirs Res 2012; 110(4):624-637
    18 Bhansali A,Walia R,Bhansali S.Efficacy and safety of autologous bone marrow derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study. Cell Transplant 2013; 11(9):103-117
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Xiao-Lin Hao, Xiu-Ling Ye, Zhong-Chen Zhang. ,/et al.Clinical observation of diabetic retinopathy after transplantation of autologous stem cell in diabetic patients. Guoji Yanke Zazhi( Int Eye Sci) 2014;14(9):1702-1704

Copy
Share
Article Metrics
  • Abstract:1474
  • PDF: 1197
  • HTML: 0
  • Cited by: 0
Publication History
  • Received:March 26,2014
  • Revised:August 04,2014
  • Online: August 19,2014