Home > Archive>Volume 13, Issue 11, 2013 >2174-2178. DOI:10.3980/j.issn.1672-5123.2013.11.03
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Effects of buddleja officinalis total flavonoids on serum testosterone level of castrated male rats with xeroma
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National Natural Science Foundation of China(No. 30772824 ); the Research Fund for the Doctoral Program of Higher Education of Ninistry of Education, China(No. 200805410004); Natural Science Foundation of Hunan Province, China(No. 07JJ3049); Research Foundation of Science and Technology Agency of Hunan Province, China(No. 2009FJ3001); Postgraduate Innovating Foundation of Hunan Province, China; Ophthalmology Key Discipline Projects of China State Administration of Traditional Chinese Medicine; Ophthalmology and Otolaryngology of Chinese Medicine Key Discipline Projects of Hunan Province, China

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    Abstract:

    AIM:To observe buddleja officinalis total flavonoids' effect on the basal tear secretion amount, tear film stability, lacrimal gland histomorphology and serum testosterone level of castrated male rat model with xeroma, to study the mechanism of rat xeroma caused by buddleja officinalis total flavones' anti-sex hormones disorders.

    MEATHODS: A total of 150 Wistar male rats of 1 month old, weighted about 200g, were randomly divided into 5 groups with 30 rats in each group with A representing normal group; B representing sham operation group; C representing surgery control group; D representing group treated with androgen; E representing group treated with buddleja officinalis total flavonoids. For the groups C, D, E, the bilateral testicle and epididymis were excised; For group B, scrota were incised without removal of the testicles, as the sham operation group; For group A, nothing was done. One week after modeling when the wound was to be healed, drug was given to each group. Respectively at the 1st month, 3rd, and 5th months after treatment, 10 rats were randomly selected in each group, to receive Schirmer I test, tear breakup time measurement. Blood serum testosterone levels were tested in the fifth month.

    RESUITS: For groups D and E, the Schirmer I test measurements were significantly higher than that of group C(P<0.05), tear film breakup time was significantly longer than that of group C(P<0.05). Serum testosterone levels in groups C and E were significantly lower than that in groups A, B, D(P<0.01).

    CONCLUSION: Decreased androgen levels can lead to xeroma, and removal of bilateral testes and epididymis can successfully establish the animal models of xeroma in rats caused by decreased androgen levels. Buddleja officinalis total flavonoids have androgenic effect, which produces the similar treatment effect of xeroma with testosterone propionate. Buddleja officinalis total flavonoids may become a new treatment for xeroma.

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Hai-Zhong Li, Qing-Hua Peng, Fen Wang,/et al.Effects of buddleja officinalis total flavonoids on serum testosterone level of castrated male rats with xeroma. Guoji Yanke Zazhi( Int Eye Sci) 2013;13(11):2174-2178

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Publication History
  • Received:July 23,2013
  • Revised:October 15,2013
  • Online: October 28,2013
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