Abstract:AIM: To elevate the diagnostic accuracy and guide the clinical treatment of central serous chorioretinopathy(CSCR)by means of multifocal electroretinogram(mf-ERG)at presentation and after resolution of the acute phase.
METHODS: A comparative observational case series group and a normal sample group were set. Thirty-one eyes of 31 patients with unilateral CSCR were examined. Both eyes underwent complete ophthalmological examination, which included measurement of best-corrected visual acuity, fluorescein angiography, OCT and mf-ERG recording. The results were compared with the corresponding findings of 30 normal volunteers of the same age.
RESULTS: At presentation, the averaged mean retinal response density of the mf-ERG of the affected eyes in area 1 was 60.54±18.20 nV/degree2, 45.43% lower compared to the normal controls(P<0.01), and in area 2 was 38.12±10.81 nV/degree2, 37.42% lower compared to the normal controls(P<0.05). After regression of CSCR, the averaged mean retinal response density of the mf-ERG of the affected eyes in area 1 was 93.71±14.13nV/degree2, 15.53% lower compared to normal controls(P<0.05), and in area 2 was 51.16±10.34 nV/degree2, 16.01% lower compared to the normal controls(P<0.05). It was interesting that 8 of 31 fellow non-affected eyes showed abnormal values, with an averaged mean retinal response density of mf-ERG in area 1(62.41 nV /degree2). In the remaining 23 eyes, the mf-ERG values were within normal limits.
CONCLUSION: Multifocal electroretinography is favorable in the clinical treatment and the following observation of central serous chorioretinopathy. It may play an important role in the diagnosis, pathogenic condition evaluation and prognosis of CSC.
