Clinical observation of flap-free LASEK combined mitomycin C and LASEK on the treatment of moderate and low myopia

Abstract:

AIM: To compare the clinical effectivity of flap-free LASEK combined mitomycin C(MMC)and LASEK for moderate and low myopia, to assess the safety and effectiveness of flap-free LASEK combined MMC surgery.

METHODS: Forty-four patients eighty-six eyes(-2.00- -7.00D)were divided randomly into two groups, group A and group B. Group A underwent flap-free LASEK combined MMC, group B underwent common LASEK. The uncorrected visual acuity(UCVA)scores were detected in 1 week,1 month, 3 months after surgery, the haze scores were detected in 1 week,10 days,1 month, 3,6 months after surgery. All subjective pain scores were evaluated in 1 day, 4 days, 7 days after the surgery. The days of corneal epithelium healing were recorded.

RESULTS: The difference of the UCVA had no statistical significance in 1 week, 1 month, 3 months after surgery between the two groups. The difference of haze scores had no statistical significance in 1 week, 10 days, 3 months, 6 months after surgery between the two groups, but in 1 month, haze scores were significant difference in group A and B(χ²=5.185, P<0.05), 0.5 degree haze in 1 month was statistical significant difference(χ²=10.135, P<0.05), while in 3 months there was no statistical significant difference in two groups. 1 degree haze in 1 month, 3 months were no statistical significant difference in two groups. 2 degree haze in 3 months was only one in group B, while no one in group A.The scores of pain in 1 day(χ²=38.78, P<0.05), 4 days(χ²=34.624, P<0.05)after surgery were statistical significant difference in group A and B, but the score of pain was no statistical significance in 7 days. The day of corneal epithelium healing had no statistical significant difference in two groups in 4 days, 7 days after surgery.

CONCLUSION: haze 0.5 degree was less and lighter in 1 month in flap-free LASEK surgery combined MMC than that in LASEK. Pain scores were lower in 1 day, 4 days in Flap-free LASEK surgery combined MMC than that in LASEK. There was no obviously difference in the days of corneal epithelium healing and UCVA between the two groups.