Abstract:AIM: To investigate the effects of Avastin and Lucentis on human umbilical vein endothelial cell(HUVEC)proliferation and migration and study the ways of them inhibiting neovessels.
METHODS: MTT was used to assay the different effects on proliferation of HUVEC between the same concentration of Avastin and Lucentis; Transwell was used to measure the different effects on inhibition of HUVEC between the same concentration of Avastin and Lucentis.
RESULTS: MTT showed that A value was significantly different in the respective concentration Avastin groups, Lucentis groups and control group(P<0.05), and there was no significant difference between the same concentration Avastin groups and the Lucentis groups. Transwell analysis showed that the rate of HUVEC migration was significantly different in the respective concentration Avastin groups, Lucentis groups and control group(P<0.05), and there was no significant difference between the same concentration Avastin groups and the Lucentis groups.
CONCLUSION: Avastin and Lucentis could inhibit HUVEC proliferation and migration and inhibition effects of Avastin and Lucentis on HUVEC proliferation and migration enhancement enhangced with the increasing of the drug concentration. There was no significant difference in inhibition effects on proliferation and migration of HUVEC between the same concentration of Avastin and Lucentis in vitro.
