Comparison of anterior segment changes before and after laser peripheral iridotomy by anterior segment optical coherence tomography in eyes with primary angle-closure glaucoma

Abstract:

AIM: To evaluate the changes of anterior segment configuration after laser peripheral iridotomy(LPI)in patients with primary angle-closure glaucoma(PACG)by using anterior segment optical coherence tomography(AS-OCT).

METHODS: This retrospective self control study consisted of forty-two eyes of 30 patients with PACG whose open angles were more than 180 degree. Central anterior chamber depth(ACD), opening distance(AOD), trabecular iris area(TISA)were measured using AS-OCT before and four weeks after LPI.

RESULTS: The parameters of AS-OCT on baseline were AOD 0.172±0.078μm, TISA 0.066±0.025mm² at 500μm anterior to sclera spur, and AOD 0.268±0.133μm, TISA 0.122±0.045mm² at 750μm. After LPI, the parameters were AOD 0.277±0.105μm, TISA 0.113±0.041mm² at 500μm, and AOD 0.388±0.154μm, TISA 0.194±0.063mm² at 750μm, which were significantly increased compared with the baseline(P<0.05). There was no significant difference on ACD before and after LPI(P=0.108).

CONCLUSION: PACG can be controlled by LPI resulting in an increase of AOD, TISA but not ACD.

Key words:anterior segment; optical coherence; laser peripheral iridotomy; primary angle-closure glaucoma; anterior chamber depth