Research progress of IGF-1 in regulating eyes growth

Abstract:

Eyes growth is an active process relies on the visual guidance. The retina,choroid and sclera are all involved in this process. There are a variety of signaling molecules that play an important role in regulating the eyes growth. Insulin-like growth factor-1 (IGF-1) is a powerful growth-promoting factor, and its role in the maintenance and controlling of cells growth, proliferation, differentiation, maturation and regeneration has been well recognized. There is also a wide range of expression of IGF-1 in eyes, which participate as a contributor in the occurrence and development of eye diseases. In recent years, its role of regulating the eyes growth has been widespread concerned. IGF-1s recognized role in regulating the eyes growth is reviewed in this paper.