Relationship of TGF-β and corneal wound healing for excimer laser refractive surgery
Author:
Clc Number:

R779.63

  • Article
  • | |
  • Metrics
  • |
  • Reference [25]
  • |
  • Related [20]
  • |
  • Cited by
  • | |
  • Comments
    Abstract:

    Recently,it becomes a hot study focused on transforming growth factor-β(TGF-β),as a kind of cytokine,whose biological effect and mechanism of action play an important role in corneal fibrosis and healing after surgery especially in excimer laser refractive surgery.Through some signal transduction passageway such Smad,TGF-β plays positive effect on accelerating cell proliferation,promoting extracellular matrix formation and inducing cell migration.Now we review TGF-β about its structure,receptor,signal transmission,distribution in eye,biological action and its relationship with corneal wound healing for excimer laser refractive surgery.

    Reference
    1谭佳,刘双珍.转化生长因子β在角膜屈光手术中作用的研究进展.眼视光学杂志2005;7(4):282-284,288
    2高春芳.TGFβ1基因变异与疾病相关性研究展望.世界华人消化杂志2007;15(28):2959-2965
    3 Yoshino K, Garg R, Monroy D, et al. Production and secretion of transforming growth factor beta(TGF-beta)by the human lacrimal gland.
    Curr Eye Res 1996;15(6):615-624
    4 Tripathi RC, Li J, Borisuth NS, et al. Trabecular cells of the eye express messenger RNA for transforming growth factor 2beta land secrete this cytokine. Invest Ophthalmol Vis Sci 1993;34(8):2562-2569
    5 Lee EH, Joo CK. Role of transforming growth factor-beta in transdifferentiation and fibrosis of lens epithelial cells. Invest Ophthalmol
    Vis Sci 1999;40(9):2025-2032
    6 Groneberg DA, Witt H, Adcock IM, et al. Smads as intracellular mediators of airway inflammation. Exp Lung Res 2004;30(3):223-250
    7常媛.JNK通路介导TGFβ1调控角膜基质CTGF表达和创伤后瘢痕形成的作用研究.山东大学2009年
    8 Kawasaki T, Tamura S, Kiso S, et al. Effects of growth factors on the growth and differentiation of mouse fetal liver epithelial cells in primary cultures. Gastroenterol Hepatol 2005;20(6):857-864
    9 Haber M, Cao Z, Panjwani N, et al. Effects of growth factors(EGF,PDGF-BB and TGF-beta1)on cultured equine epithelial cells and keratocytes: implications for wound healing. Vet Ophthalmol 2003;6(3):211-217
    10刘洋,张明昌,黄渝侃,等.转化生长抑制β2对牛角膜内皮细胞增生的影响.眼科研究2009;27(6):502-505
    11 Saika S, Ikeda K, Yamanaka O, et al. Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice. Lab Invest2004;84(10):1259-1270
    12 Fl gel-Koch C, Ohlmann A, Piatigorsky J, et al. Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice. Dev Dyn 2002;225(2):111-125
    13 Saika S, Saika S, Liu CY, et al.TGFbeta 2 in corneal morphogenesis during mouse embryonic development. Dev Biol 2001;240(2):419-432
    14 Dunker N, Krieglstein K. Reduced programmed cell death in the retina and defects in lens and cornea of Tgf beta 2(-/-)Tgf beta 3 (-/-)double-deficient mice. Cell Tissue Res 2003;313(1):1-10
    15严浩,胡燕华,徐惠民.转化生长因子β1对牛角膜内皮细胞外基质合成的影响.眼科新进展2006;26(8):585-587
    16晏晓明,王晓飞,吴静安.转化生长因子β调节培养的人角膜基质细胞MMP-2和MMP-9的分泌.眼科研究2000;18(4):292-294
    17李雪,徐锦堂,崔浩,等.TGF-β2局部应用对大鼠角膜碱烧伤后CD44和E-selectin mRNA表达的影响.眼科新进展2006;26(7):499-503
    18 Philips N,Keller T, Gonzalez S. TGF beta-like regulation of matrix metallopmteinases by anti-transforming growth factor-beta,and anti-transforming growth factor-beta 1 antibodies in dermal fibroblasts:Implications for wound healing. Wound Repair Regen 2004;12(1):53-59
    19刘春民,徐锦堂.转化生长因子β1对角膜碱烧伤后机体免疫细胞功能的影响.眼科研究2000;18(2)101-103
    20蒋燕铌,张明昌.洛伐他汀对大鼠角膜新生血管VEGF和TGF-β1表达的影响.国际眼科杂志2008;8(7):1331-1333
    21 Cursiefen C, Rummelt C, Kuchle M. Immunohistochemical localization of vascular endothelial growth factor,transforming growth factor alpha,and transforming growth factor batal in human corneas with neovascularization. Cornea 2000;19(4):526-533
    22王峰,石蕊,赵琳.TGF-β1 和VEGF在兔角膜缝线后新生血管形成中的表达及意义.眼科新进展2008;28(2):96-99
    23 Lee SH, Leem HS, Jeong SM, et al. Bevacizumab accelerates corneal wound healing by inhibiting TGF-β2 expression in alkali-burned mouse cornea. BMB Rep2009;42(12):800-805·
    Cited by
Get Citation

Jing Li, Zheng-Wei Shen. ,/et al.Relationship of TGF-β and corneal wound healing for excimer laser refractive surgery. Guoji Yanke Zazhi( Int Eye Sci) 2011;11(11):1935-1937

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:June 02,2011