Abstract:AIM:To survey the effect of sublingual immunotherapy in allergic conjunctivitis. METHODS:Eighty patients of seasonal and perennial allergic conjunctivitis were divided into two groups,one group was prescribed cetirizine and vitamin C for them to take orally,sodium cromoglicate or dexamethasone/chloromycetin gutta ad hibeo,meanwhile the other group was treated respectively with sublingual immunotherapy. Record the symptom pre & post immunotherapy and side-effects,and run statistical analysis to the results. RESULTS:The total effective rate in experimental group was 92.5%,while in control group was 72.5%,There were significant differences between pre & post therapy in both the two groups(P<0.05). There was no systemic adverse reactions.CONCLUSION:The sublingual immunotherapy had obvious cure effect to the seasonal and perennial allergic conjunctivitis.