The expression and distribution of α-Gal gene in various species ocular surface tissue
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National Natural Science Foundation of China (No. 81160118); Natural Science Foundation of Jiangxi Province (No. 20114BAB215029); Technology Foundation of Jiangxi Province (No. 20111BBG70026-2); Health Department Science and Technology Foundation (No.20121026); Education Department Youth Scientific Research Foundation (No.JJJ12158); National High Technology Research of China (863 project)(No. 2006AA02A131)

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    Abstract:

    AIM: To examine the α-Gal gene expression and distribution in the different species/genus and developing phase animal ocular surface tissue.METHODS: α-Gal binding assay were carried out on various animal eye sections. Photograph, slit-lamp observation on various eye showed normal corneal transparence.RESULTS: A strong α-Gal expression in invertebrates and some vertebrates ocular tissue, but no α-Gal binding in birds, fish and mammal. α-Gal expression change in the development of mice ocular surface tissue (except sclera) and display genus dependency in the different murine ocular surface tissue.CONCLUSION: This study identified specific α-Gal epitopes binding area in the ocular surface of several species and may solve the problem that naive ocular surface may be used as natural α-Gal gene knockout model/high risk immunologic rejection model or ocular surface scaffold material.

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Yi Shao, Yao Yu, Chong-Gang Pei, et al. The expression and distribution of α-Gal gene in various species ocular surface tissue. Int J Ophthalmol, 2012,5(5):543-548

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Publication History
  • Received:May 25,2012
  • Revised:September 18,2012
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