Publication trends of Leber congenital amaurosis researches: a bibliometric study during 2002-2022
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Xiao-Dong Sun and Min-Wen Zhou. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Hai Ning Road, Shanghai 200080, China. xdsun@sjtu.edu.cn; zmw8008@163.com

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Supported by the National Natural Science Foundation of China (No.82171076; No.82101159); Science and Technology Commission of Shanghai Municipality (No.20Z11900400); Shanghai Hospital Development Center (No.SHDC2020CR2040B; No.SHDC2020CR5014); Shanghai Collaborative Innovation Center for Translational Medicine (No.TM202115PT); Shanghai Sailing Program (No.22YF1435500).

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    Abstract:

    AIM: To analyze the changes in scientific output relating to Leber congenital amaurosis (LCA) and forecast the study trends in this field. METHODS: All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science (WOS) database. We analyzed the quantity (number of publications), quality (citation and H-index) and development trends (relative research interest, RRI) of published LCA research over the last two decades. Moreover, VOSviewer software was applied to define the co-occurrence network of keywords in this field. RESULTS: A total of 2158 publications were ultimately examined. We found that the focus on LCA kept rising and peaked in 2015 and 2018, which is consistent with the development trend of gene therapy. The USA has contributed most to this field with 1162 publications, 56 674 citations and the highest H-index value (116). The keywords analysis was divided into five clusters to show the hotspots in the field of LCA, namely mechanism-related, genotype-related, local phenotype-related, system phenotype-related, and therapy-related. We also identified gene therapy and anti-retinal degeneration therapy as a major focus in recent years. CONCLUSION: Our study illustrates historical research process and future development trends in LCA field. This may help to guide the orientation for further clinical diagnosis, treatment and scientific research.

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Xiao-Xu Huang, Yi-Min Wang, Min-Yue Xie, et al. Publication trends of Leber congenital amaurosis researches: a bibliometric study during 2002-2022. Int J Ophthalmol, 2024,17(8):1501-1509

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Publication History
  • Received:February 03,2024
  • Revised:April 12,2024
  • Adopted:
  • Online: July 23,2024
  • Published: