Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis
Author:
Corresponding Author:

Qiong Qin. School of Basic Medical Sciences, Capital Medical University, No.10 Youanmen Wai Xitoutiao, Beijing 100069, China. qqin@ccmu.edu.cn

Affiliation:

Clc Number:

Fund Project:

Supported by Capital Medical University Scientific Research Grant for Undergraduate Students (No.XSKY2023026).

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    Age-related macular degeneration (AMD) is a complicated disease that causes irreversible visual impairment. Increasing evidences pointed retinal pigment epithelia (RPE) cells as the decisive cell involved in the progress of AMD, and the function of anti-oxidant capacity of PRE plays a fundamental physiological role. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative genes. Its functions of protecting RPE cells against oxidative stress (OS) and ensuing physiological changes, including inflammation, mitochondrial damage and autophagy dysregulation, have already been elucidated. Understanding the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD pathogenesis. For the first time, this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis, including proteins and miRNAs, and their underlying molecular mechanisms, which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.

    Reference
    Related
    Cited by
Get Citation

Zi-Ling Hu, Yu-Xuan Wang, Zi-Yue Lin, et al. Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis. Int J Ophthalmol, 2024,17(7):1344-1362

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:July 24,2023
  • Revised:March 06,2024
  • Adopted:
  • Online: June 25,2024
  • Published: