Mesenchymal stem cells for repairing glaucomatous optic nerve
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Liu-Zhi Zeng. Department of Ophthalmology, Chengdu First People’s Hospital, No.18 Wanxiang North Road, High-tech Zone, Chengdu 610095, Sichuan Province, China. 676681961@qq.com

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Supported by Science & Technology Department of Sichuan Province (No.2021YFS0214).

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    Abstract:

    Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells (RGCs) and axons. Currently, there is no effective method to address the cause of RGCs degeneration. However, studies on neuroprotective strategies for optic neuropathy have increased in recent years. Cell replacement and neuroprotection are major strategies for treating glaucoma and optic neuropathy. Regenerative medicine research into the repair of optic nerve damage using stem cells has received considerable attention. Stem cells possess the potential for multidirectional differentiation abilities and are capable of producing RGC-friendly microenvironments through paracrine effects. This article reviews a thorough researches of recent advances and approaches in stem cell repair of optic nerve injury, raising the controversies and unresolved issues surrounding the future of stem cells.

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Bai-Yu Hu, Mei Xin, Ming Chen, et al. Mesenchymal stem cells for repairing glaucomatous optic nerve. Int J Ophthalmol, 2024,17(4):748-760

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Publication History
  • Received:September 09,2023
  • Revised:January 09,2024
  • Adopted:
  • Online: March 26,2024
  • Published: