Dry eye rate and its relationship with disease stage in patients with primary hypertension: a cross-sectional study in Vietnam
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Le Viet Thang. Military Hospital 103, Vietnam Military Medical University, 261 Phung Hung, Ha Dong, Ha Noi 100000, Vietnam. lethangviet@yahoo.co.uk

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    Abstract:

    AIM: To determine the dry eye (DE) rate and its relationship with disease stage in patients with primary hypertension. METHODS: A cross-sectional study included 432 patients with primary hypertension (with an equal number of patients in each group: 144 in stage I, II, and III hypertension) and 144 healthy subjects as a control group. The Ocular Surface Disease Index (OSDI) and Schirmer I test without anesthetics were conducted on all 576 subjects. Subjects with OSDI scores <13 and Schirmer I values equal to or under 10 mm were diagnosed with DE. RESULTS: The ratio of DE in hypertension patients was higher than in the control group (41.7% versus 18.8%; P<0.001). The proportion of patients with DE increased gradually according to the hypertension stage: 27.1% in stage I, 40.3% in stage II, and 57.6% in stage III, P<0.001. Age, duration of hypertension, plasma urea, creatinine, and high-sensitivity C-reactive protein (CRP-hs) levels in hypertension patients with DE were higher than those without DE, P<0.001. Advanced age, a long duration of hypertension, diabetes mellitus, elevated plasma creatinine, and CRP-hs levels were independent factors associated with DE in primary hypertension patients, P<0.001. CONCLUSION: DE is a common disorder associated with advanced age, a long duration of hypertension, diabetes mellitus, elevated plasma CRP-hs, and creatinine levels in patients with primary hypertension.

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Tran Tat Thang, Pham Hong Phuong, Nguyen Sa Huynh, et al. Dry eye rate and its relationship with disease stage in patients with primary hypertension: a cross-sectional study in Vietnam. Int J Ophthalmol, 2024,17(4):653-658

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Publication History
  • Received:September 25,2023
  • Revised:November 28,2023
  • Adopted:
  • Online: March 26,2024
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