Treatment of lacrimal gland adenoid cystic carcinoma: a systematic review and Meta-analysis
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Jian-Min Ma. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China. jmma@sina.com; yanhaihan@mail.ccmu.edu.cn

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Supported by Natural Science Foundation of Beijing (No.7222025); Beijing Hospitals Authority’ Ascent Plan (No.DFL20190201); Beijing Science and Technology Rising Star Program.

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    Abstract:

    AIM: To evaluate lacrimal gland adenoid cystic carcinoma (LGACC) of prognosis in patients who underwent different treatment regimens. METHODS: We searched PubMed, EMBASE, and the Cochrane Library for studies done on the treatment of LGACC, between January 1987 and April 2022. A Meta-analysis was conducted to pool the 5-year overall survival rate (OR), and the 5-year recurrence rate (RR) and 5-year metastasis rate (MR) were assessed. RESULTS: The 30 studies involved 585 patients were included in the Meta-analysis. The pooled 5-year OR with surgery alone was 50%, the 5-year RR was 63%, and the 5-year MR was 34%. The pooled 5-year OR with surgery and adjuvant radiotherapy combined was 67% (95%CI 61%,73%), the 5-year RR was 41%, and the 5-year MR was 35%. The pooled 5-year OR with surgery and adjuvant chemoradiotherapy combined was 72% (95%CI 59%, 84%), the 5-year RR was 48%, and the 5-year MR was 36%. The pooled 5-year OR with surgery, intra-arterial cytoreductive chemotherapy, and adjuvant chemoradiotherapy combined was 78% (95%CI 68%, 89%), the 5-year RR was 15%, and the 5-year MR was 27%. CONCLUSION: Comprehensive treatment is more effective than surgery alone. Surgery combined with intra-arterial chemotherapy and adjuvant chemoradiotherapy seems to add value to the therapeutic effect of comprehensive treatment of LGACC but further high-quality research is required to validate this.

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Hai-Han Yan, Rui Liu, Nan Wang, et al. Treatment of lacrimal gland adenoid cystic carcinoma: a systematic review and Meta-analysis. Int J Ophthalmol, 2024,17(1):164-172

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Publication History
  • Received:November 07,2022
  • Revised:November 17,2023
  • Adopted:
  • Online: December 21,2023
  • Published: