Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis
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Xin-Yan Dou. Department of Ophthalmology, Shanghai Wusong Central Hospital, Baoshan District, No.216 Mudanjiang Road, Baoshan District, Shanghai 200940, China. douxinyan0116@126.com

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    Abstract:

    AIM: To assess the efficacy of ketotifen in treating allergic conjunctivitis. METHODS: A systematic search of systematic reviews and Meta-analyses was conducted on the PubMed and Web Science of Science until October 2021 to address this knowledge gap. Mean difference with 95%CI and P values were used to assess the efficacy of ketotifen. The heterogeneity (I2) was used to evaluate the impact of heterogeneity. RESULTS: Eight randomized controlled trials (RCTs) involving 1589 patients were included in this Meta-analysis. The results revealed that after treating with ketotifen, itching (MD=-0.91, 95%CI: -1.63 to -0.20, I2=94%, P=0.01), tearing (MD=-0.40, 95%CI: -0.61 to -0.18, I2=75%, P=0.0003) and total signs and symptoms (MD=-0.85, 95%CI: -1.12 to -0.58, I2=0, P<0.00001) showed better benefit effect compared to the placebo group. CONCLUSION: Topical ketotifen is an effective treatment for patients with allergic conjunctivitis.

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Xin-Yan Dou, Wei Zhang. Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis. Int J Ophthalmol, 2023,16(2):286-292

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Publication History
  • Received:February 25,2022
  • Revised:October 30,2022
  • Adopted:
  • Online: February 02,2023
  • Published: