Age-related changes of lens thickness and density in different age phases
Author:
Corresponding Author:

Xue-Min Li. Department of Ophthalmology, Peking University Third Hospital, No.49 North Garden Road, Haidian District, Beijing 10091, China. lxmlxm66@sina.com

Affiliation:

Clc Number:

Fund Project:

Supported by the National Science Foundation of Beijing Municipality (No.7202229).

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM: To explore the changes in lens thickness and density with age. METHODS: A Chinese population-based retrospective study was performed. A total of 497 individuals (490 right eyes and 495 left eyes), ranging from 3 to 69 years old were included. Lens images obtained from IOL Master 700 were used to measure lens thickness and density. Piecewise regression model was chosen to illustrate the relationship of lens thickness and density with age. RESULTS: The proportion of people aged 3-18, 19-40, over 40 was 38.6%, 50.9% and 10.5% respectively. The whole lens thickness decreased with age during the first 7 years of life, kept stable from 8 to 16 years old, and then increased at the rate of about 27 µm per year. The thickness of the lens cortex and nucleus tended to decrease first and then increase with age, which was dependent on age stages. The whole lens density also decreased with age until 7 years old. The increasing rate of lens density was different in different age groups. The whole lens density increased rapidly from 7 to 22 years old and slowed down after 22 years old. Similarly, the changing tendency of lens cortical and nuclear density differed in different age phases. CONCLUSION: Both lens thickness and density are significantly associated with age, whereas they do not change linearly with age. Moreover, it is necessary to increase the population over 40 years old and conduct further research.

    Reference
    Related
    Cited by
Get Citation

Yin-Hao Wang, Jing Zhong, Xue-Min Li. Age-related changes of lens thickness and density in different age phases. Int J Ophthalmol, 2022,15(10):1591-1597

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:October 04,2021
  • Revised:February 14,2022
  • Adopted:
  • Online: September 21,2022
  • Published: