Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial
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Ning-Li Wang and Shi-Fei Wei. Beijing Tongren Hospital, 1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China. wningli@vip.163.com; wsfstep2015@163.com

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Supported by the National Natural Science Foundation of China (No.82071000); the Beijing Science Foundation for Distinguished Yong Scholars (No.JQ20029); the Capital Health Research and Development of Special (No.2020-2-1081); Supported by the Beijing Municipal Administration of Hospitals Incubating Program (No.PX2022007); the Primary Scientific Research Foundation for the Junior Researcher in Beijing Tongren Hospital, Capital Medical University (No.2020-YJJ-ZZL-011).

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    Abstract:

    AIM: To assess the effect of 0.01% atropine eye drops on intraocular pressure (IOP) in myopic children. METHODS: A placebo-controlled, double-masked, randomized study. Totally 220 children aged 6 to 12y with myopia ranging from -1.00 to -6.00 D in both eyes were enrolled. Children were randomized in a 1:1 ratio to either 0.01% atropine eye drops or a placebo group using generated random numbers. All participants underwent the examination of IOP and cycloplegic refraction at baseline, 6 and 12mo. The change of IOP and the proportion of subjects with increased IOP in atropine and placebo groups were compared. RESULTS: Of 220 children, 117 were boys (53.2%). A total of 159 (72.3%) participants completed the follow-up at the 1-year study. At baseline, the mean IOP was 15.74 mm Hg (95%CI, 15.13 to 16.34 mm Hg) for the 0.01% atropine group and 15.59 mm Hg (95%CI, 15.00 to 16.19 mm Hg) for placebo group (mean difference, 0.14 mm Hg; P=0.743) after adjusting for central corneal thickness at baseline. At one year follow-up, the mean change of IOP was 0.16 mm Hg (95%CI, -0.43 to 0.76 mm Hg) for the 0.01% atropine group and -0.11 mm Hg (95%CI, -0.71 to 0.50 mm Hg) for placebo group (mean difference, 0.27 mm Hg; P=0.525) after adjusting for central corneal thickness. The 51.4% of children have increased IOP in the 0.01% atropine group, compared with 45.9% in the placebo group (P=0.511). CONCLUSION: The 0.01% atropine eye drops do not significantly affect the risk of elevated IOP. It is relatively safer to use in the studies that try to minimize myopia progression. However, a further long-duration study is required to be validated.

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Javaria Bukhari, Shi-Fei Wei, Shi-Ming Li, et al. Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial. Int J Ophthalmol, 2022,15(9):1431-1436

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Publication History
  • Received:October 09,2021
  • Revised:July 05,2022
  • Adopted:
  • Online: September 01,2022
  • Published: