Clinical research of EX-PRESS drainage device and modified trabeculectomy combined with intravitreal conbercept treatment for neovascular glaucoma
Author:
Corresponding Author:

Peng Li. Department of Ophthalmology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an 710054, Shaanxi Province, China. drlipeng@126.com

Affiliation:

Clc Number:

Fund Project:

Supported by the Social Development Project of Shaanxi Provincial Department of Science and Technology (No.2020SF-167); General Social Scientific Research Plan Project of Shaanxi Provincial Education Department in 2021 (No.21JK0891); The Innovation and Entrepreneurship Program for College Students at Xi'an Medical College (No.121521113).

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM: To evaluate the efficacy and safety of modified trabeculectomy (experimental group) and implantation of EX-PRESS drainage device (control group), combined with intravitreal conbercept injection for neovascular glaucoma (NVG). METHODS: Totally 30 patients with NVG were selected from June 2014 to June 2017, and randomly divided into experimental group and control group. All patients were underwent intravitreal conbercept (0.5 mg/0.05 mL) treatment before surgery. Modified trabeculectomy was performed in MT group, while EX-PRESS drainage device implantation was performed in EX group. The success rates, best corrected visual acuity (BCVA), intraocular pressure (IOP), filtering bleb and complications were observed and compared. RESULTS: The differences of success rate, BCVA and filtering bleb were not statistically significant 12mo after the surgery (P>0.05), however, the difference of IOP at 1d, 1wk, 1, 3, and 6mo after surgery was statistically significant (Ftime=390.64, Ptime<0.0001) between two groups. The interactions between two groups in the given time showed no significant difference (Fintergroup×time=0.181, Pintergroup×time=0.57), and also there was no significant difference in IOP between the two groups (F=3.16, P=0.09). The results of pairwise comparison at each time point showed no significant difference in IOP between 1d and 1wk, 3 and 6, 3mo and 12mo after surgery (P>0.05), while the results at other time point indicate statistical differences (P<0.05). CONCLUSION: The modified trabeculectomy and the implantation of EX-PRESS drainage device have clinical application value in reducing IOP and postoperative complications of refractory NVG.

    Reference
    Related
    Cited by
Get Citation

Peng Li, Qing Liu, Xiao-Min Liu, et al. Clinical research of EX-PRESS drainage device and modified trabeculectomy combined with intravitreal conbercept treatment for neovascular glaucoma. Int J Ophthalmol, 2022,15(2):242-247

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:April 19,2021
  • Revised:September 17,2021
  • Adopted:
  • Online: January 26,2022
  • Published: