In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review
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Li-Ke Xie, Department of Ophthalmology, Ophthalmology Hospital of China Academy of Traditional Chinese Medicine, 33 Lugu Road, Shijingshan District, Beijing 100040, China. bjxielike@sina.com

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Supported by National Natural Science Foundation of China (No.82174445); China Post-doctoral Science Foundation in 2019 (No.2019M650987); Natural Science Foundation of Beijing of China (No.7192235).

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    Abstract:

    Retinitis pigmentosa (RP) is the most recognized inherited retinal disorder involving progressive photoreceptors degeneration which eventually causes blindness. However, the pathogenesis of RP is still unclear, making it difficult to establish satisfying treatments. Evidence have been found to support the theory that vascular dysfunction is associated with the progression of RP. Optical coherence tomography angiography (OCTA) is a newly developed technology that enables visualization as well as quantitative assessment of retinal and choroidal vasculature non-invasively. Advances in OCTA have opened a window for in-depth understanding of RP pathogenesis. Here, we propose a hypothesis of RP pathogenesis based on the current OCTA findings in RP, which includes four stages and two important key factors, vascular dysfunction and microglia activation. Further, we discuss the future animal experiments needed and how advanced OCTA technology can help to further verity the hypothesis. The final goal is to explore potential treatment options with enhanced understanding of RP pathogenesis.

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Bing-Wen Lu, Guo-Jun Chao, Gai-Ping Wu, et al. In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review. Int J Ophthalmol, 2021,14(12):1979-1985

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Publication History
  • Received:May 26,2021
  • Revised:September 13,2021
  • Adopted:
  • Online: November 25,2021
  • Published: