Latanoprost eye drops induce conjunctival lymphatic vessel development
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Zhen-Yong Zhang. Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Lanxi Road 164, Shanghai 200062, China. zzyly818@sina.com

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Supported by Shanghai No.6 Hospital Group (No.18-LY-03); Putuo Hospital Shanghai University of Traditional Chinese Medicine (No.2017301A).

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    Abstract:

    AIM: To investigate the effect of latanoprost eye drops on the conjunctival lymphatics. METHODS: Twenty-four healthy New Zealand White rabbits weighing 1.5 to 2.0 kg were randomly divided into three groups: latanoprost group (n=8) administered with latanoprost eye drops once a day for 2mo, carteolol group (n=8) administered with carteolol eye drops once a day for 2mo, and control group (n=8) without any treatment. The conjunctival tissues in the three groups were extracted to investigate the expression levels of 5’-nucleotidase (5’-Nase) by Western blot, reverse transcription-polymerase chain reaction (RT-PCR), and immunofluorescence staining, respectively. RESULTS: The protein expression level of 5’-Nase was significantly higher in latanoprost group than carteolol group (F=231.175, P<0.001) and control group (P<0.001), while there was no significant difference between the carteolol group and the control group (P>0.05). The mRNA expression level of 5’-Nase in the latanoprost group was also significantly higher than carteolol group (F=71.169 P<0.005) and control group (P<0.005). The conjunctival lymphatics were positive immunofluorescence stained with the 5’-Nase antibodies in the latanoprost group and not stained in the control group. CONCLUSION: Latanoprost eye drops can induce conjunctival lymphangiogenesis which may be concerned in clinical implications.

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Kai Ma, Qing-Song Li, Cheng-Juan Yin, et al. Latanoprost eye drops induce conjunctival lymphatic vessel development. Int J Ophthalmol, 2021,14(9):1345-1349

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Publication History
  • Received:November 11,2020
  • Revised:May 21,2021
  • Adopted:
  • Online: August 23,2021
  • Published: