Home > Archive>Volume 14, Issue 8, 2021 >1179-1184. DOI:10.18240/ijo.2021.08.07
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Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study
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Corresponding Author:

Ning-Li Wang. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology&Visual Science Key Lab, No.1. Dong Jiao Min Xiang, Beijing 100730, China. nlwang66@sina.com

Fund Project:

Supported in part by the Ministry of Science and Technology of the National “Eleventh Five-Year” Science and Technology Program in China (No.2007BAI1 8B08); Beijijng Municipal Science and Technology Commission, Capital Characteristic Clinic Project (No.Z171100001017040).

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    Abstract:

    AIM: To report the progression rate (PR) to primary angle closure (PAC) following laser peripheral iridotomy (LPI) in PAC suspects (PACS). METHODS: Prospective, randomized controlled interventional clinical trial conducted at the Handan Eye Hospital, China. Totally 134 bilateral PACS, defined as non-visibility of the posterior trabecular meshwork for ≥180 degrees on gonioscopy were randomly assigned to undergo LPI in one eye. Gonioscopy and Goldmann applanation tonometry were performed prior to, on day 7 and 12mo post LPI. RESULTS: Eighty of 134 patients (59.7%) could be followed up at one year. The mean intraocular pressure (IOP) in treated eyes was 15.9±2.6 mm Hg at baseline, 15.4±3.0 mm Hg on day 7; 16.5±2.9 mm Hg at one month, and 15.5±2.9 mm Hg at 12mo; the IOP in untreated eyes was similar (P=0.834). One or more quadrants of the angle opened in 93.7% of the LPI treated eyes, but 67.0% (53/79) remained closed in two or more quadrants. The PR to PAC in untreated eyes was 3.75% and one developed acute angle-closure glaucoma (AACG); the PR to PAC in treated eyes was 2.5% and none had developed peripheral anterior synechia (PAS) or AACG. CONCLUSION: LPI can open some of the occludable angle in the majority of eyes with PACS, but 67% continue to have non-visibility of the trabecular meshwork for over 180 degrees.

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Da-Peng Mou, Yuan-Bo Liang, Su-Jie Fan,/et al.Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study. Int J Ophthalmol, 2021,14(8):1179-1184

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Publication History
  • Received:January 02,2021
  • Revised:May 17,2021
  • Online: June 28,2021
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