Immunologic mechanism of fungal keratitis
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Shao-Zhen Zhao. Tianjin Medical University Eye Hospital, 251 Fukang Road, Xiqing District, Tianjin 300384, China. zhaosz1997@sina.com

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Supported by the Natural Science Foundation of Tianjin (No.19JCYBJC25700); Clinical Key Discipline (Specialty) Construction Project of Tianjin (No.TJLCZDXKM002); Science and Technology Projects of Social Development of Tianjin Binhai New District (No.BHXQKJXM-SF-2018-05); Science and Technology Projects of Health Commission of Tianjin Binhai New District (No.2019BWKZ008).

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    Abstract:

    Fungal keratitis (FK) is a refractory disease that poses a serious threat to vision, with common risk factors like eye trauma, contact lens wearing, topical corticosteroids and antibiotic abuse. Nowadays, topical and systemic anti-fungal drugs and ocular surgeries are still the main therapeutic modalities. However, the pathogenesis of FK, especially the immunologic mechanism within it, has not yet been deeply clarified. A better understanding of the pathogenesis of FK is imperative for more effective therapies and prognosis. Meanwhile, the immune protection strategies are also urgently required to manage FK. This review highlights recent advances in the immunologic mechanism in the pathogenesis of FK, in hope of providing valuable reference information for more effective anti-fungal treatment.

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Rui-Bo Yang, Li-Ping Wu, Xiao-Xiao Lu, et al. Immunologic mechanism of fungal keratitis. Int J Ophthalmol, 2021,14(7):1100-1106

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Publication History
  • Received:December 15,2020
  • Revised:January 14,2021
  • Adopted:
  • Online: May 25,2021
  • Published: