Corneal stromal mesenchymal stem cells: reconstructing a bioactive cornea and repairing the corneal limbus and stromal microenvironment
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Yao Wang. Department of Ophthalmology, First Hospital of Xi’an; Shaanxi Institute of Ophthalmology, Shaanxi Provincial Key Lab of Ophthalmology, Clinical Research Center for Ophthalmology Diseases of Shaanxi Province; the First Affiliated Hospital of Northwest University, Xi’an 710002, Shaanxi Province, China. wangyao0605@163.com

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Supported by the National Key R&D Program of China (No.2016YFC1100100); the Key R&D Program of Shaanxi Province (No.2018ZDXM-SF-056); the Health and Family Planning Research Fund Project of Shaanxi Province (No.2016C004); the Key Research and Development Program of Shaanxi Province (No.2019SF-196); the Research Talent Project of Xi’an Municipal Health Commission (No.J201902037).

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    Abstract:

    Corneal stroma-derived mesenchymal stem cells (CS-MSCs) are mainly distributed in the anterior part of the corneal stroma near the corneal limbal stem cells (LSCs). CS-MSCs are stem cells with self-renewal and multidirectional differentiation potential. A large amount of data confirmed that CS-MSCs can be induced to differentiate into functional keratocytes in vitro, which is the motive force for maintaining corneal transparency and producing a normal corneal stroma. CS-MSCs are also an important component of the limbal microenvironment. Furthermore, they are of great significance in the reconstruction of ocular surface tissue and tissue engineering for active biocornea construction. In this paper, the localization and biological characteristics of CS-MSCs, the use of CS-MSCs to reconstruct a tissue-engineered active biocornea, and the repair of the limbal and matrix microenvironment by CS-MSCs are reviewed, and their application prospects are discussed.

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Xian-Ning Liu, Sheng-Li Mi, Yun Chen, et al. Corneal stromal mesenchymal stem cells: reconstructing a bioactive cornea and repairing the corneal limbus and stromal microenvironment. Int J Ophthalmol, 2021,14(3):448-455

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Publication History
  • Received:September 22,2020
  • Revised:November 17,2020
  • Adopted:
  • Online: February 24,2021
  • Published: