The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review
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Wen-Fang Zhang. Department of Ophthalmology, Lanzhou University Second Hospital, Linxia Road Cuiying Gate No.82, Lanzhou 730000, Gansu Province, China. drwanna@sina.com

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    Abstract:

    AIM: To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume (MPV), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and the presence and severity of diabetic retinopathy (DR). METHODS: We searched for eligible studies from PubMed, EMBASE, Web of Science and CNKI up to December 13, 2017. Standardized mean difference (SMD) calculated with confidence interval (CI) of 95% was used to estimate the values of those indices. RESULTS: A total of 31 studies were included in the present Meta-analysis. As compared with type 2 diabetes mellitus (T2DM) patients without DR, the values of MPV, PDW, NLR, and PLR were higher in patients with DR (SMD=0.67; 95%CI: 0.36 to 0.98; SMD=0.51; 95%CI: 0.27 to 0.75; SMD=0.77; 95%CI: 0.49 to 1.05 and SMD=1.18; 95%CI: 0.07 to 2.28). Additionally, it was also observed that MPV was closely correlated with the severity of DR. CONCLUSION: MPV, PDW, NLR, and PLR could be recommended as diagnostic biomarkers for DR, and MPV could be applied to assess the severity of DR.

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Wen-Juan Luo, Wen-Fang Zhang. The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review. Int J Ophthalmol, 2019,12(2):312-323

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Publication History
  • Received:April 29,2018
  • Revised:August 02,2018
  • Adopted:
  • Online: January 03,2019
  • Published: