The prognosis of trabeculectomy in primary angle- closure glaucoma patients
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Xiao-He Lu. Department of Ophthalmology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510280, Guangdong Province, China. luxh63@163.com

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    Abstract:

    AIM: To evaluate whether the level of thrombospondin-1 (TSP-1) in aqueous humor can predict the prognosis of trabeculectomy in patients with primary angle-closure glaucoma (PACG). METHODS: This case-control study involved 26 patients with PACG who experienced a failed trabeculectomy (case group) and 78 age- and sex-matched patients with PACG who underwent successful trabeculectomy (control group). Aqueous humor was collected at the time of trabeculectomy and tested for TSP-1 and TGF-β2 levels with an enzyme-linked immunosorbent assay method. Logistic regression modeling was used to assess the risk factors for failed trabeculectomy. RESULTS: The mean TSP-1 aqueous concentrations were significantly higher in the case group (20.67±9.79 ng/mL) than the control group (5.17±2.29 ng/mL) (P<0.001). The transforming growth factor-β2 (TGF-β2) aqueous concentrations were significantly different between the case and control group, at 3633.25 and 1090.24 pg/mL, respectively (P<0.001). Logistic regression analysis revealed TSP-1 level as an independent risk factor for a failed trabeculectomy (OR=3.540; 95%CI=1.092-11.482). CONCLUSION: The aqueous humor TSP-1 and TGF-β2 levels are higher in PACG eyes with failed trabeculectomy than with successful trabeculectomy at one year. The aqueous humor TSP-1 level is an independent risk factor associated with failed trabeculectomy.

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Jun-Dong Zhu, Li-Lian Xie, Zhi-Yuan Li, et al. The prognosis of trabeculectomy in primary angle- closure glaucoma patients. Int J Ophthalmol, 2019,12(1):66-72

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Publication History
  • Received:May 04,2018
  • Revised:June 03,2018
  • Adopted:
  • Online: January 03,2019
  • Published: