Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure
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Qing-Hua Peng; Han-Yu Tan. Hunan University of Traditional Chinese Medicine 410208, Hunan Province, China. pqh410007@126.com; thy612@126.com

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Supported by the National Natural Science Foundation of China (No.81273807); Key Projects of Graduate Innovation Fund of Hunan Province (No.CX2017B434; No.CX2017B426); Projects of Hunan Educational Research Foundation (No.17C1221); 225 Engineering Project of High Lever Health Professionals of Hunan Province; Key Discipline Project of Ophthalmology of Traditional Chinese Medicine of State Administration of TCM; Key Discipline Project of Otorhinolaryngology of TCM of Hunan Province; Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine (No.2017TP1018).

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    Abstract:

    The study investigated the effects of Qingguang’an II (a Chinese medicinal preparation) on expressions of OX42 protein and interleukin-1β (IL-1β) mRNA of retinal microglia cells of rats with chronic high intraocular pressure (IOP). SD rats were randomly divided into 6 groups, that were: A: blank group; B: model group; C: Qingguang’an II low dose group; D: Qingguang’an II medium dose group; E: Qingguang’an II high dose group; F: Yimaikang disket (a Chinese medicinal preparation) group. Experimental rats in B, C, D, E, F groups were established the model of chronic high IOP by cauterizing of superficial scleral vein. Tissues of eyes were obtained after intragastric administration for 2 and 4wk. At the time-point of 2wk, OX42 protein and IL-1β mRNA in group B were statistically expressed in higher level comparing with other groups (P<0.05). Moreover, at the time-point of 4wk, OX42 protein and IL-1β mRNA in groups C, D and E were statistically expressed in lower level comparing with group F (P<0.05). Besides, OX42 protein and IL-1β mRNA in groups C and D were statistically expressed in higher level comparing with group E (P<0.05). OX42 protein and IL-1β mRNA in groups C and D were expressed in similar level (P>0.05). The study indicated that, in the protection of optic nerve of rats with chronic high IOP, the high dose of Qingguang’an II at the time-point of 4wk was the better choice.

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Ya-Sha Zhou, Jian Xu, Jun Peng, et al. Effect of Qingguang’an II on expressions of OX42 protein and IL-1β mRNA of retinal microglia cells of rats with chronic high intraocular pressure. Int J Ophthalmol, 2018,11(2):326-328

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Publication History
  • Received:May 05,2017
  • Revised:December 22,2017
  • Adopted:
  • Online: February 06,2018
  • Published: