Effect of two different doses of intravitreal bevacizumab with temporal retina-sparing laser photocoagulation for retinopathy of prematurity
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Yu Cheol Kim. Department of Ophthalmology, Keimyung University School of Medicine, Dongsan Medical Center, #56, Dalseong-ro, Jung-gu, Daegu 41931, Korea. eyedr@dsmc.or.kr; Hochan Cho. Department of Internal Medicine, Keimyung University School of Medicine, Dongsan Medical Center, #56, Dalseong-ro, Jung-gu, Daegu 41931, Korea. hochan3632@gmail.com

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Supported by the National Research Foundation of Korea (NRF) Grant Funded by the Korean Government (MSIP; No.2014R1A5A2010008); the Research Promoting Grant from the Keimyung University Donsan Medical Center in 2011.

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    Abstract:

    This study aims to compare the efficacy and safety between two different doses of intravitreal bevacizumab (IVB) injection with temporal retina-sparing laser (TRSL) photocoagulation for retinopathy of prematurity (ROP). We retrospectively evaluated 22 eyes of ROP infants who underwent IVB combined with partial TRSL for stage 3+ zone I or posterior zone II ROP. Laser photocoagulation was applied on the avascular retina, sparing two-disc-diameter width temporal avascular area anterior to ridge. A half dose (0.625 mg) or minimal dose (0.25 mg) of IVB was conducted. Four eyes in minimal dose group were retreated with IVB and laser photocoagulation on the spared retina. Of those 4 retreated eyes, three developed preretinal hemorrhage around the ridge after the first treatment, resulting in fibrotic macular dragging. A half dose of IVB may be more effective than a minimal dose with partial TRSL for ROP. Preretinal hemorrhage may be a harbinger of poor prognosis.

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A Young Choi, Hochan Cho, Yu Cheol Kim. Effect of two different doses of intravitreal bevacizumab with temporal retina-sparing laser photocoagulation for retinopathy of prematurity. Int J Ophthalmol, 2018,11(1):166-169

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Publication History
  • Received:July 14,2017
  • Revised:September 18,2017
  • Adopted:
  • Online: January 09,2018
  • Published: