The role of microglia in the progression of glaucomatous neurodegeneration- a review
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Jing-Ming Shi. Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China. sjm93cn@126.com

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    Abstract:

    Glaucoma is a serious leading cause of irreversible blindness worldwide. Reducing intraocular pressure (IOP) does not always stop glaucomatous neurodegeneration and the optic nerve may continue to be damaged in the normal IOP. Microglial activity has been recognized to play essential roles in pathogenesis of the central nervous system (CNS) as well as retinal ganglion cell (RGC) survival. The relationship between the neurodegeneration and the microglia cells in glaucoma is very complicated and still remains unclear. In the present review, we summarize the recent studies of mechanisms of microglia in glaucoma neurodegeneration, which might provide new ways to treat glaucoma.

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Hui-Lan Zeng, Jing-Ming Shi. The role of microglia in the progression of glaucomatous neurodegeneration- a review. Int J Ophthalmol, 2018,11(1):143-149

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Publication History
  • Received:February 25,2017
  • Revised:August 28,2017
  • Adopted:
  • Online: January 09,2018
  • Published: