The role of elastic fibers in pathogenesis of conjunctivochalasis
Author:
Corresponding Author:

Xing-Ru Zhang. Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China. zhangxingru928@163.com

Affiliation:

Clc Number:

Fund Project:

Supported by the Key Medical Discipline Project of Shanghai Municipal Health Bureau- Ophthalmology (No.ZK2015A20); the Health System Independent Innovation Science Foundation of Shanghai Putuo District; Plateau Science,Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine.

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    The PubMed, MEDLINE databases and China National Knowledge Infrastructure (CNKI) were searched for information regarding the etiology and pathogenesis of conjunctivochalasis (CCh) and the synthesis and degradation of elastic fibers. After analysis of the literature, we found elastic fibers was a complex protein molecule from the structure and composition; the degradation of elastic fibers was one of the histopathological features of the disease; the vast majority of the factors related to the pathogenesis of CCh ultimately pointed to abnormal elastic fibers. By reasonably speculating, we considered that abnormal elastic fibers cause the conjunctival relaxation. In conclusion, we hypothesize that elastic fibers play an important role in the pathogenesis of CCh. Studies on the mechanism of synthesis, degradation of elastic fibers are helpful to clarify the pathogenesis of the disease and to find effective treatment methods.

    Reference
    Related
    Cited by
Get Citation

Jing-Yun Gan, Qing-Song Li, Zhen-Yong Zhang, et al. The role of elastic fibers in pathogenesis of conjunctivochalasis. Int J Ophthalmol, 2017,10(9):1465-1473

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:November 22,2016
  • Revised:March 23,2017
  • Adopted:
  • Online: September 05,2017
  • Published: