Diabetes and risk of glaucoma: systematic review and a Meta-analysis of prospective cohort studies
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Xiang-Wu Chen. Department of Outpatient Service, the Eye Hospital of Wenzhou Medical University, Wenzhou 310020, Zhejiang Province, China. chenxiangwu_fd@sina.com

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Supported by the Plan of Wenzhou Science and Technology (No.Y20160439).

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    Abstract:

    AIM: To quantify the association between diabetes and glaucoma using Meta-analysis. METHODS: PubMed and Embase were searched using medical subject headings and key words related to diabetes and glaucoma. The inclusion criteria were: 1) the study design was a prospective cohort study; 2) the exposure of interest was diabetes; 3) the outcome of interest was primary open angle glaucoma (POAG); 4) risk ratios (RR) and the corresponding 95% confidence interval (CI). Data were pooled using fixed effects models to take into account heterogeneity between studies. Seven prospective studies were selected. Diabetes increased the incidence of glaucoma by 36% (OR=1.36, 95% CI=1.25-1.50). There was no evidence of statistical heterogeneity (I2=0, P=0.53) or publication bias (the funnel plot did not identify obvious asymmetry). RESULTS: Seven prospective cohort studies were incorporated in this Meta-analysis. The pooled RR of the association between POAG and diabetes based on the risk estimates of the seven cohort studies was 1.36 (95%CI=1.24-1.50), with no significant heterogeneity across studies (I2=0; P=0.526). The sensitivity analysis yielded a range of RRs from 1.34 (95%CI=1.22-1.48) to1.40 (95%CI=1.18-1.67). CONCLUSION: Diabetes is associated with a significantly increased risk of glaucoma.

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Ying-Xi Zhao, Xiang-Wu Chen. Diabetes and risk of glaucoma: systematic review and a Meta-analysis of prospective cohort studies. Int J Ophthalmol, 2017,10(9):1430-1435

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Publication History
  • Received:December 19,2016
  • Revised:June 26,2017
  • Adopted:
  • Online: September 05,2017
  • Published: