Suppressive effect of microRNA-143 in retinoblastoma
Author:
Corresponding Author:

Yan-Qin Feng. Department of Ophthalmology, Affiliated Hospital of Yan’an University, Yan’an 716000, Shaanxi Province, China. fengyanqin2016@163.com

Affiliation:

Clc Number:

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM: To investigate microRNA-143 expression and effect on suppression of retinoblastoma (RB) cells. METHODS: The expression of microRNA-143 was investigated and compared in normal human retina tissue samples and in RB cell lines of Y79 and Weri1. The microRNA-143 mimics were transfected into the RB cell lines separately, and its effect on RB cell lines was detected using reverse-transcription quantitative polymerase chain reaction and Western blotting methods. RESULTS: The microRNA-143 expression was significantly suppressed in RB cell lines. Overexpression of microRNA-143 significantly lowered cell viability and invasion of the RB cell lines, and increased the number of apoptotic cells. Meanwhile, the Bax expression was up-regulated and much higher in the microRNA-143 mimics transfected group than that in the negative control and the microRNA-143 inhibitor groups. CONCLUSION: MicroRNA-143 exhibits suppressive effects in RB. The current study provides the perspective of a potential therapeutic treatment for RB.

    Reference
    Related
    Cited by
Get Citation

Li-Lun Wang, Hai-Feng Hu, Yan-Qin Feng. Suppressive effect of microRNA-143 in retinoblastoma. Int J Ophthalmol, 2016,9(11):1584-1590

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:April 24,2016
  • Revised:June 20,2016
  • Adopted:
  • Online: November 09,2016
  • Published: