Inhibiting the effect of 90Sr-90Y ophthalmic applicators on rat corneal neovascularization induced by sutures
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Wen-Song Zhang. Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130033, Jilin Province, China. zhangzhou89@sina.com

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Supported by National Natural Science Foundation (No.81300727); the Research Fund of Jilin Provincial Science and Technology Department (No.20160101011JC).

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    Abstract:

    AIM: To investigate a practical technique used to inhibit corneal angiogenesis with a 90Sr-90Y ophthalmic applicator. METHODS: A 90Sr-90Y ophthalmic applicator was detected with a radioactive nuclide application treatment healthy protection standard. The applicator used was produced through medical dosimetry research; it had a concave applicator add measured the applicator temperature, serviceable humidity range, applicator appearance status, applicator radiation homogeneity, radioautography, and radiological safety of the original applicator surface. A vessel model was established using newborn rats, with sutures around the corneal limbus. Corneal neovascularization (CNV) were observed with a slit lamp. The new vessel length and response area were measured. RESULTS: Low-dose radiation can inhibit CNV after corneal sutures. The absorbed dose of the applicator (0.046 Gy/s) was safe for the treatment of it. The lengths of new vessels and the areas of new vessels were lower than the new born vessel rat group (P<0.01). CONCLUSION: The optimal radiation dose emitting from the applicator can be safe and potentially used in humans.

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Hong-Yan Zhou, Shuang Wang, Hong Zhang, et al. Inhibiting the effect of 90Sr-90Y ophthalmic applicators on rat corneal neovascularization induced by sutures. Int J Ophthalmol, 2016,9(9):1251-1254

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Publication History
  • Received:January 21,2016
  • Revised:April 11,2016
  • Adopted:
  • Online: September 12,2016
  • Published: