Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis
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Xing-Chao Shentu. Eye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, No.88 Jiefang Road, Hangzhou 310000, Zhejiang Province, China. stxc20030304@aliyun.com

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Supported by the National Natural Science Foundation of China (No.81371000); the Foundation from Health and Family Planning Commission of Zhejiang Province (WKJ-ZJ-17); Zhejiang Key Laboratory Fund of China (No.2011E10006).

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    Abstract:

    AIM: To explore the relationship between metabolic risk factors and dry eye syndrome (DES). METHODS: Retrieved studies on the association of metabolic syndrome risk factors (hypertension, hyperglycemia, obesity, and hyperlipidemia) and DES were collected from PubMed, Web of Science, and the Cochrane Library in December 2015. Odds ratio (OR) with 95% confidence interval (CI) were pooled to evaluate the final relationship. Subgroup analyses were conducted according to diagnostic criteria of DES. RESULTS: Nine cross-sectional studies and three case-control studies were included in this Meta-analysis. The pooled results showed that people with hypertension, hyperglycemia, and hyperlipidemia had a higher risk of suffering from DES (P<0.05), especially the typical DES symptoms. On the other hand, obesity did not increase the risk of DES. CONCLUSION: The present Meta-analysis suggests that all metabolic risk factors except obesity were risk factors for DES.

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Ye-Lei Tang, Ya-Lan Cheng, Yu-Ping Ren, et al. Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis. Int J Ophthalmol, 2016,9(7):1038-1045

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Publication History
  • Received:March 08,2016
  • Revised:May 04,2016
  • Adopted:
  • Online: July 12,2016
  • Published: