Effect of periocular injection of celecoxib and propranolol on ocular level of vascular endothelial growth factor in a diabetic mouse model
Author:
Corresponding Author:

Gholamreza Houshmand. Departmentof Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Mailbox: 159, Ahvaz 61357-15794, Khuzestan, Iran. dr.houshmand_pharmaco@yahoo.com

Affiliation:

Clc Number:

Fund Project:

Supported by the Ahvaz Jundishapur University of Medical Sciences (No. IORC-9203).

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM: To investigate the effects of periocular injection of propranolol and celecoxib on ocular levels of vascular endothelial growth factor (VEGF) in a diabetic mouse model. METHODS: Forty 4-6wk BALB-C male mice weighing 20-25 g were used. The study groups included: non-diabetic control (group 1), diabetic control (group 2), diabetic propranolol (group 3), and diabetic celecoxib (group 4). After induction of type 1 diabetes by streptozotocin, propranolol (10 μg) and celecoxib (200 μg dissolved in carboxymethylcellulose 0.5%) were injected periocularly. The ocular level of VEGF was measured in all the study groups using enzyme-linked immuno sorbent assay (ELISA) method. RESULTS: Ocular VEGF level was significantly increased (1.25 fold) in the diabetic control group when compared to the non-diabetic group one week after induction with streptozotocin (P=0.002). Both periocular propranolol and celecoxib significantly reduced ocular VEGF levels (P=0.047 and P<0.001, respectively). The effect was more pronounced with celecoxib. CONCLUSION: The periocular administration of propranolol and celecoxib can significantly reduce ocular VEGF levels in a diabetic mouse model.

    Reference
    Related
    Cited by
Get Citation

Saman Nassiri, Gholamreza Houshmand, Mostafa Feghhi, et al. Effect of periocular injection of celecoxib and propranolol on ocular level of vascular endothelial growth factor in a diabetic mouse model. Int J Ophthalmol, 2016,9(6):821-824

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:June 15,2015
  • Revised:October 12,2015
  • Adopted:
  • Online: June 16,2016
  • Published: