Primary Sj?gren’s syndrome related optic neuritis
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The 12th Five-Year Plan National Science and Technology Support Program, China (No.2012BAI08B06)

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    Abstract:

    AIM:To determine the clinical features, diagnosis and treatment of the primary Sj?gren syndrome (SS) related optic neuritis.METHODS:The clinical data of 8 patients (12 eyes) with primary SS related optic neuritis were analyzed retrospectively.RESULTS: Eight of 128 consecutive patients with optic neuritis resulted from varied causes fulfilled the diagnostic criteria for the primary SS. They presented initially with the signs and symptoms of non-specific optic neuritis, and 5 patients presenting without dryness showed a chronic inflammation of submandibular gland or parotid gland, and lymphocyte infiltration was demonstrated by labial gland biopsy in 2 patients. There were serum positive titers for anti-Sj?gren syndrome A (SSA) in 7 patients and anti-Sj?gren syndrome B (SSB) in 8 patients. Anti-aquaporin-4 (AQP4) antibody was negative in all the 8 patients. Both glucocorticoids and immunosuppressive agent were administered, and visual acuity elevated in 8 eyes (66.7%), 3 patients (37.5%) recurred in the follow-up.CONCLUSION:Primary SS related optic neuritis is less common and easily misdiagnosed. The conventional therapies for optic neuritis could not control the recurrence.

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Wei-Qiang Tang, Shi-Hui Wei. Primary Sj?gren’s syndrome related optic neuritis. Int J Ophthalmol, 2013,6(6):888-891

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Publication History
  • Received:April 21,2013
  • Revised:July 30,2013
  • Adopted:July 30,2013
  • Online: December 22,2013
  • Published: