Association between lumican gene -1554 T/C polymorphism and high myopia in Asian population:a meta-analysis
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    Abstract:

    AIM:To investigate the association between lumican gene -1554 T/C polymorphism and high myopiasusceptibility.METHODS: We searched the published literature in the Medline, Embase, and CBM databases from inception to July 2013. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.RESLUTS:Seven case-control studies with a total of 1 233 cases and 936 controls were included. A statistical significant association with high myopia was observed in the recessive model (TT vs CT+CC:OR=1.92; 95%CI=1.14-3.23) and codominant model (TT vs CT:OR=1.81, 95%CI=1.19-2.75).CONCLUSION: The present meta-analysis suggested that lumican -1554 T/C polymorphism might be moderately associated with high myopia susceptibility. This conclusion warrants confirmation by further studies.

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Xuan Liao, Xu-Bo Yang, Meng Liao, et al. Association between lumican gene -1554 T/C polymorphism and high myopia in Asian population:a meta-analysis. Int J Ophthalmol, 2013,6(5):696-701

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Publication History
  • Received:September 28,2012
  • Revised:August 08,2013
  • Adopted:May 24,2013
  • Online: October 21,2013
  • Published: