An increased expression of CD40/CD40L costimula- tory molecules in erythema nodosum of patients with Behçet's disease
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National Natural Science Foundation of China (No.30400490); Beijing Natural Science Foundation of China (No.7052023); Foundation of Bureau of Guangdong Traditional Chinese Medicine, China (No.1050171)

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    Abstract:

    AIM: To investigate the expression and the possible implication of CD40/CD40L costimulatory molecules in erythema nodosum of patients with BehÇet's disease. METHODS: Sampling was done from erythema nodosum of 5 patients with BehÇet's disease and normal skin of 2 healthy individuals. Immunohistochemical staining was performed to examine the expression of CD4, CD8, CD19, CD68, HLA-DR, CD40 and CD40L molecules in the obtained tissues.
    RESULTS: Approximately 90% of epidermic cells in erythema nodosum expressed CD40 moleculeIn the dermis and subcutaneous tissue, a significantly increased number of CD4+Tcells, CD8+Tcells, CD19+cells, CD68+cells, HLA-DR+cells, CD40L+cells, and CD40+cells were observed in the erythema nodosum as compared with that in normal skin. Double staining showed that CD40L molecules were expressed on 45% of CD4+ T cells. CD40 molecules were expressed on 100% CD68+ cells and 59.2% of HLA-DR+cells respectively. CONCLUSION: A number of CD40/CD40L costimulatory molecules are upregulated in the erythema nodosum of patients with BehÇet's disease.

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Hong Wang, Pei-Zeng Yang, Xiao-Yan Peng, et al. An increased expression of CD40/CD40L costimula- tory molecules in erythema nodosum of patients with Behçet's disease. Int J Ophthalmol, 2009,2(1):12-15

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Publication History
  • Received:November 25,2008
  • Revised:January 10,2009
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